VDR functions are a vital part of the development metabolism and general homeostasis of the organism. Vitamin D/VDR plays a role in a variety of other biological processes, including the immune system control the reproduction of cells and gene expression in addition to its traditional function in controlling intestinal absorption of calcium and bone tissue.
When liganded VDR forms homo- or heterodimers with RXR and initiates the transcription of target genes by binding to DNA response elements. This process is influenced by an interaction between the bounding domain for ligands (LBD) and the heterodimerization domain. A variety of natural changes in the LBD of VDR result in a vitamin D resistance phenotype, and studies of mutagenesis have revealed https://www.dataroomapps.net/data-management-made-simple-how-virtual-data-rooms-can-simplify-your-complex-business-processes/ areas within the ligand binding domain that are vital for heterodimerization.
Unliganded VDR interacts with regulatory regions in cWnt, as well as Sonic hedgehog gene promoters. This interaction is essential for the stimulation of these pathways in the postnatal period of hair. Inhibition by 1,25(OH2D3) of the VDR-b catenin interaction results in repression of these genes.
VDR-null mouse behavior is characterized by impaired motor performance, balance and ability to swim. This phenotype is mediated by an impairment in the cellular expression of a variety of cytoskeletal proteins, including myofilaments and actin. The changes in these proteins have been observed to be linked to an increase in the number of fibers as well as a reduction in their diameter.